Various mediators are involved in this process, including transforming growth‐factor beta (TGFβ), and molecules produced by supportive tumor stroma, namely epidermal growth factor (EGF) and colony‐stimulating factor 1 (CSF‐1) (Giampieri et al., 2009; Wyckoff et al., 2007). This evidence concerns the gene TGFB1 and neoplasm.