This is further supported by the finding that 12(S)-HETE activates the pro-metastatic transcription factor ZEB1 in endothelial cells, assisting the formation of cancer spheroid-triggered “circular chemorepellent induced defects” (CCIDs) [14], which resemble entry gates for the tumour into the vasculature [15]. The gene discussed is ZEB1; the disease is neoplasm.