Evidence for the pro-invasive contribution of 12(S)-HETE is provided by a CRC in vivo model in which the double amount of ALOX12-overexpressing SW480 cells [secreting four to fivefold more 12(S)-HETE as compared to control cells] [41] were detected in the vicinity of the lung blood vessels after transgrafting them into the rear flank of SCID mice [13]. The gene discussed is ALOX12; the disease is colorectal carcinoma.