Further, 12(S)-HETE, which is metabolised by the lipoxygenases ALOX12 and ALOX15 [8] and by cytochrome-P450-1A1 (CYP1A1) [9, 10], induces the metastatic spreading of prostate carcinoma cells [11]. The gene discussed is CYP1A1; the disease is prostate carcinoma.