Shen et al. [40] found that the del6/del6 genotype of TS 3′-UTR was associated with significantly increased gastric cancer risk, Sumen et al. [41] suggested that 3R allele, 2R/3R and 3R/3R genotypes were risk factors for gastric cancer, whereas Araújo et al. [55] did not obtain a significant relationship between TS 5′-UTR 2R/3R and 3′-UTR del6/ins6 polymorphisms and gastric cancer susceptibility. Here, TYMS is linked to gastric cancer.