Based on analysis within the initiation phase of CM reprogramming, we identified a cocktail of three genes, FoxM1, Id1, and Jnk3‐shRNA (FIJs), induced CMs to re‐enter the cell cycle with complete mitosis and cytokinesis, and significantly improved cardiac function and reduced fibrosis after myocardial infarction. Here, MAPK10 is linked to myocardial infarction.