PLD2 and breast cancer: PLD2 overexpression is connected to breast cancer cell growth, proliferation, and metastasis (Henkels et al., 2013) through interactions between PLD2 and the mammalian target of rapamycin (mTOR) pathway, stabilization of mutant p53 and promotion of factors involved in cancer cell proliferation (Gomez-Cambronero, 2014).