Demographics = age, gender, race, region, income, and education; health behaviors = smoking status and alcohol use; chronic medical conditions = cancer, chronic lung disease, coronary artery disease, diabetes, hypertension, obesity, stroke, and Morisky medication adherence index; biomarkers = hs-CRP, Cystatin C, ACR, and eGFR; functional status measures = weakness, exhaustion, and low physical activity. The gene discussed is CST3; the disease is cancer.