We found significant negative correlation between the change in numbers of IL17-producing cells (by IL17 Elispot) from baseline to week 12 on treatment and the change in Trans STA score (r = -0.39, p = 0.04) and the change in Trans PDA score (r = -0.68, p = 0.007) from baseline to 12 weeks on treatment (Fig. 3). Here, IL17A is linked to Patent ductus arteriosus.