To investigate the relationship between these three hyper-editing sites and the splicing patterns of HMOX2 (Figure 3A), we calculated the percent spliced in (PSI, detailed in Method) of exon 3 in HMOX2. We found that the PSIs of tumor samples with at least one of three hyper-editing sites were significantly higher than those without them (P = 4.39e−02, Wilcoxon signed rank test, Figure 3B). Here, HMOX2 is linked to neoplasm.