AHR and hepatocellular carcinoma: Indeed, we found that XIAP (X-linked inhibitor of apoptosis), expressed significantly lower in edit+ than in edit- metastatic samples (P = 3.27e−02, t-test, Supplementary Figure 10), were reported to promote metastasis or tumor recurrence in hepatocellular carcinoma [38] and in papillary thyroid carcinoma [39], and AHR, expressed significantly higher in edit+ than in edit- metastatic samples (P = 5.7e−03, t-test, Supplementary Figure 10), were also reported to be associated with metastasis and may be a potential therapeutic target in the treatment of metastatic breast cancer [40].