Rap1GAP is a critical tumor suppressor gene that is downregulated in multiple cancers such as prostate cancer [3], breast cancer [4], oropharyngeal squamous cell carcinoma [5], pancreatic cancer [6], thyroid carcinoma [7], melanoma [8], colorectal cancer [9], B-cell lymphomas [10], kidney cancer [11], and acute myeloid leukemia [12]. This evidence concerns the gene RAP1GAP and familial pancreatic carcinoma.