Analysis of MARCKS stromal staining intensity in our present series (data not shown) showed a moderate to strong expression in fibroblasts more frequent in IBC (31% of the samples) than in non-IBC (24% of the samples; p = 0.009, Fisher's exact test), which might contribute to more cancer-associated fibroblasts activation in IBC and higher metastatic potential. The gene discussed is MARCKS; the disease is cancer.