The molecular interaction of maspin with the uPAR/pro-uPA complex also quenches the uPA proteolytic cascade by triggering low-density lipoprotein receptor (LRP)-mediated internalization, which helps explain the tumor suppressive activities of either secreted maspin or purified maspin protein in blocking tumor cell detachment, motility, invasion and tumor-induced angiogenesis [8, 10, 11, 23, 24]. The gene discussed is VLDLR; the disease is neoplasm.