The BRCA1 variant c.5406+2T>C described herein was found in a 69-year-old woman, investigated for BRCA mutational status because she was affected by breast cancer (breast cancer onset age: 60 years), and because other tumors, including breast cancer, were present in her family, which suggested the presence of an HBOC syndrome (Figure 1a). This evidence concerns the gene BRCA1 and breast carcinoma.