Various growth factors, such as epidermal growth factor (EGF), TGF-β and insulin-like growth factor-1 induced EMT in lung cancer and EMT was correlated with metastases and invasiveness of lung cancer.17, 38, 39, 40, 41, 42 This study provided a novel mechanism by which EMT is regulated in lung cancer. The gene discussed is EGF; the disease is lung cancer.