IL10RA and inflammatory bowel disease: Consequently, sequencing-based studies conducted in specific subsets of IBD patients (i.e., children younger than 2 years, infantile onset IBD, and familial clusters of affected individuals44) have discovered rare functional variants in genes implicated in the pathogenesis of both VEO (XIAP45, FOXP346, IL10RA, IL10RB, IL1047, 48, 49, and Il17REL42) and adult-onset disease (GSDMB21).