NCF4 and inflammatory bowel disease: Furthermore, of 53 rare and novel non-synonymous variants (out of which 37 are possibly deleterious with CADD score on PHRED scale above 10) in genes recognized previously as being associated with monogenic IBD (in a list provided by Uhlig et al. 5), two homozygote variants were found; NCF4 p.Arg8Trp in one affected adult and WAS p.Glu131Lys (rs146220228, GMAF = 0.0008) in affected child and one adult patient, but not in healthy controls.