Moreover, obese animals showed higher (P < 0.05) transcript levels of the lipogenic genes Pparg, Srebf1, Mogat2 and Dgat1 as well as a moderate-to-severe hepatic steatosis evidenced by the staining of the lipid droplet-coating protein adipophilin in liver sections (Fig. 2A–B and Supplemental Fig. 1). Here, SREBF1 is linked to fatty liver disease.