Accordingly, sleeve-gastrectomized rats exhibited a tendency towards a downregulation in hepatic Pparg (P = 0.084) and Srebf1 (P = 0.153) transcription factors as well as lower (P < 0.05) mRNA levels of Mogat2 and Dgat1 and mild steatosis evidenced by adipophilin staining (Fig. 2B–C and Supplemental Fig. 1). The gene discussed is SREBF1; the disease is steatosis.