Due to the association of inflammation in cancer development, the prognostic significance of several inflammation biomarkers and hematological indices, including the C-reactive protein (CRP), Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and neutrophil-platelet score (NPS) have been evaluated in various malignancies. The gene discussed is CRP; the disease is cancer.