AQP4 and neuromyelitis optica: We therefore concluded that it was unlikely that the antibodies that reacted with CSF114(N-Glc) had been elicited specifically to a human protein or a simple mutation to a human protein as is the case with neuromyelitis optica (NMO), which is an autoimmune disease with demyelination of the spinal cord and optic nerve with clinical similarity to MS but specifically marked by anti-human aquaporin-4 antibodies20, 21.