Since these genes are involved in the nuclear factor-kB (NF-kB) signaling pathway, which is a critical pathway in tumor growth17, 18, we measured NF-kB activity in the 2774 stable cell lines and showed that it was inhibited by 60–70% in C/2774 cells relative to its activity in Vec/2774 cells (Fig. 2D). This evidence concerns the gene NFKB1 and neoplasm.