FOXO3 and neuroblastoma: Recent data from Chen SJ et al. suggest that overexpression of TRPM2-S results in increased proliferation through phosphatidylinositol 3-kinase/Akt and ERK pathways in the neuroblastoma SH-SY5Y cell lines, while overexpression of TRPM2-L confers protection against oxidative stress-induced cell death through FOXO3a and SOD46, 47.