The Py117 tumour curves were modelled using a repeated measures model revealing a significant difference between 12 Gy+isotype versus 12 Gy+PD-1 Ab and 12 Gy+PD-1 Ab+CTLA-4 Ab with P=0.002 and 0.0004, respectively (Fig. 3b). The gene discussed is CTLA4; the disease is neoplasm.