Similar observation of apoptosis induction and cell viability suppression by PHLDB3 knockdown were also found in lung cancer H460 (wild-type p53) and H1299 (p53 null) cells (Supplementary Fig. 2), indicating that the oncogenic properties of PHLDB3 are not limited to colon cancer cells. The gene discussed is TP53; the disease is malignant colon neoplasm.