Similar observation of apoptosis induction and cell viability suppression by PHLDB3 knockdown were also found in lung cancer H460 (wild-type p53) and H1299 (p53 null) cells (Supplementary Fig. 2), indicating that the oncogenic properties of PHLDB3 are not limited to colon cancer cells. Here, PHLDB3 is linked to malignant colon neoplasm.