First, since MDM2 also binds to and suppresses TAp73, a p53 homolog that shares high structural similarity with p53 and transcriptionally activates most of the important p53 target genes, leading to tumour suppression39, 40, it is possible that PHLDB3 may collaborate with MDM2 to inactivate TAp73. This evidence concerns the gene TP53 and neoplasm.