Furthermore, adipokines and cytokines [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β], induced by fat tissues in obese individuals, trigger a metabolic imbalance (IR, type 2 diabetes mellitus, etc.)by causing subclinical systemic inflammation (25). This evidence concerns the gene IL6 and type 2 diabetes mellitus.