Seven of these patients were found to carry two pathogenic variants including one biallelic ATM carrier with a clinical diagnosis of ataxia-telangiectasia, two ATM/BRCA2 carriers, one BRIP1/BRCA2 carrier, one BRCA1/CHEK2 carrier, one BARD1/PALB2 carrier, and one CHEK2/PALB2 carrier. The gene discussed is BRCA1; the disease is ataxia telangiectasia.