Consistent with this hypothesis, RAW 264.7 cells, in which an NPC phenotype was induced by treatment with U18666A (a widely-used pharmacological inducer of NPC phenotypes in wild-type cells that targets NPC1)44, had an impaired ability to clear non-pathogenicMsm (Figure 3D;p<0.05) relative to untreated RAW 264.7 macrophages. The gene discussed is NPC1; the disease is nasopharyngeal carcinoma.