Cynaropicrin has been shown to possess various biological activities and has demonstrated extraordinary pharmacologic properties such as anti-hepatitis C virus, anti-parasitic, anti-tumor, anti-hyperlipidemic, antifeedant, antispasmodic, anti-photoaging agent, activation of bitter sensory receptors, suppression of NF-κB, and anti-inflammatory properties. Here, NFKB1 is linked to neoplasm.