Consistent with the data obtained from the xenograft MDA-MB-231 and MDA-MB-468 tumor tissues, CITED2 silencing reduced protein expression of VEGFA121, VEGFA165, and VEGFA189 isoforms in MDA-MB-231 cells grown in vitro, while having no effect on VEGFA isoform expression in MDA-MB-468 cells (Figure 3B). The gene discussed is CITED2; the disease is neoplasm.