Interestingly, the length of astrocytes protrusions was significantly decreased in 231BR/PTEN co-cultures compared to co-cultures with 231BR/CTL cells (Figure 6D–6FD, p < 0,001), indicating that the 231BR/PTEN tumor cells have a reduced activation status compared to 231BR/CTL. The gene discussed is PTEN; the disease is neoplasm.