We used cell lines reproducing the most frequent molecular alterations in NSCLC: H1299 (p53 deletion, RASSF1A methylation), H1650 (EGF-R mutation, RASSF1A methylation, p53 mutation, CDKN2A deletion), H1975 (EGF-R mutation, p53 mutation, R273H, PI3K mutation, CDKN2A deletion), and A549 (RASSF1A methylation, RasSer12, CDKN2A deletion, Lkb1/STK11 mutation). The gene discussed is RASSF1; the disease is non-small cell lung carcinoma.