The CDC42-binding kinase, MRCKβ, regulates actin organization in endothelial cell contacts and cell migration in cancer cells (44, 45), aldolase-A regulates lamellipodia formation (46), and FHOD3 is important for maintenance of F-actin polymerization at EC junctions and is required for vessel lumenization in angiogenesis (47). Here, CDC42BPB is linked to cancer.