The CDC42-binding kinase, MRCKβ, regulates actin organization in endothelial cell contacts and cell migration in cancer cells (44, 45), aldolase-A regulates lamellipodia formation (46), and FHOD3 is important for maintenance of F-actin polymerization at EC junctions and is required for vessel lumenization in angiogenesis (47). This evidence concerns the gene FHOD3 and cancer.