We found hypermutated tumors as identified by CGS: 17 (8%) in J-CRC and two (3%) in US-CRC (Fig. 2a and b), generally correlated with DNA mismatch repair deficiency (MMR-D) as detected by standard clinical IHC evaluation for MMR proteins (MLH1, MSH2, MSH6, and PMS2). Here, MLH1 is linked to colorectal carcinoma.