ERBB2 and neoplasm: Interestingly, patients in Cluster 2 (n = 8 tumors) with ERBB2 mutations were associated with smallest tumor size, significantly less lymphatic invasion (p < 0.01) and early stage (p < 0.05), while patients in Cluster 5 (n = 29 tumors) harboring PTEN mutations exhibited significantly more lymphatic (p < 0.05) and vascular invasion (p < 0.01) with more metastasis.