In the solid tumor category, two alterations in APC were diagnostic: one in a patient with hepatoblastoma and a family history consistent with familial adenomatous polyposis (FAP; p.R1114) and one associated with newly appreciated Gardner’s syndrome (p.E1554fs) in a 14-year-old boy with pilomatricomas and epidermoid cysts prior to his carcinoma diagnosis. The gene discussed is APC; the disease is carcinoma.