EGFR and pneumonitis: A multivariate Cox model showed that independent predictors of OS were older age (HR 1.25, 95% CI, 1.04–1.50, P = 0.019), poor PS (HR 2.47, 95% CI, 2.03–2.98, P<0.001), wild-type or not investigated EGFR (HR 2.08, 95% CI, 1.63–2.67, P<0.001), stage IV (HR 1.46, 95% CI, 1.18–1.82, P<0.001), pre-existing ILD (HR 1.90, 95% CI, 1.41–2.53, P<0.001), and pneumonitis (HR 1.53, 95% CI, 1.09–2.09, P = 0.015).