USP8 and adenoma: There was no statistical difference between the score intensity in normal pituitary vs. adenoma tissue (mean cytoplasmic USP8 2.16±0.40 vs 1.69±0.73, p = 0.12, respectively, Fig 4D, and mean nuclear USP8 2.00±0.00 vs 1.57±0.80, p = 0.16, respectively, Fig 4E).