Sporadic AD is associated with multiple genetic variations of small effect (e.g., most GWAS loci) or moderate effect (e.g., APOE-ε4 [17] and TREM2 rs75932628 T-allele [18, 19]), and could be influenced by other risk factors (e.g., head trauma [20], diabetes [21] and aging [22]). The gene discussed is APOE; the disease is Alzheimer disease.