The p-mTOR overexpression was strongly associated with depth of invasion (OR = 1.63, 95%CI: 1.08–2.45, P = 0.02, Fig 4a), and tumor stage (OR = 1.73, 95%CI: 1.29–2.32, P < 0.001, Fig 4b). The gene discussed is MTOR; the disease is neoplasm.