SCARB1 and hyperalphalipoproteinemia: SCARB1 plays an important role in intestinal absorption of β-carotene into the epithelial cells [16], and the common intronic rs2278986 SNP in the SCARB1 gene has been reported to be an independent predictor of SCARB1 protein levels and high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia [17].