Based on the integrative regulatory network for primary state HOXD10 and its target gene IGFBP3 are targets of multiple overexpressed miRNAs (miR-20a, miR-32, miR-135a and miR-629 for HOXD10, and miR-19a, miR-19b and miR-375 for IGFBP3) which might be the reason for the suppression of the mentioned genes in the primary prostate tumor. This evidence concerns the gene HOXD10 and prostate neoplasm.