Consistent with the hypothesis that a predominant Th2 tumor microenvironment relates to a functional Th1 response during BCG treatment, we confirmed a positive correlation between GATA3/T-bet ratio prior BCG induction and levels of serum neopterin (rs = 0.533, p = 0.008), IFN-γ (rs = 0.505, p = 0.013) and KTR (rs = 0.508, p = 0.018) after the first BCG instillation, respectively. Here, GATA3 is linked to neoplasm.