MAP2K4 and neoplasm: MiR-16 has also been verified to act as a tumor suppressor by downregulating BCL-2, whereas miR-150, by negatively regulating p53 expression, was confirmed to be an oncogene.14, 15 MiR-27a can function as an oncogene by targeting MAP2K4, and inhibition of miR-27a increases MAP2K4 expression, which subsequently inhibits MG63 cell proliferation and migration.16