In mammals, three Tribble homologs exist: TRIB1, TRIB2, and TRIB3, and all are associated with human malignancies.42, 43, 44 Several studies indicated that TRIB2 can act as an oncogene involved in a mouse model of AML by inhibiting transcription factor C/EBPα. Here, TRIB1 is linked to acute myeloid leukemia.