NLRP3 and rheumatoid arthritis: In particular, nucleotide-binding domain and leucine-rich repeat pyrin 3 (NLRP3) inflammasomes, the most well-established inflammasome, were recently reported to have an epistatic relation with RA.22 Namely, genetic mutations in the NLRP3 protein are closely associated with the susceptibility to and severity of RA.23 Moreover, NLRP3 inflammasome activity is enhanced in patients with RA.24 Therefore, targeting NLRP3 inflammasomes or their downstream pathways can be an effective strategy for attenuating RA.