RAB8A and cancer: Multiple Rabs are associated with secretory granules/vesicles.32 Rab8 is a small GTPase that controls cell surface structures such as primary cilia, filopodia and neurites by regulating the actin cytoskeleton and the polarized delivery of receptors and vesicles to these specialized membrane domains.33 Both Rab8 and Rab11 has important roles in regulating cell migration.34, 35 Rab8 was also demonstrated present in TNTs and transferred between cancer cells.36 Forced expression of dominant negative Rab11 strongly impairs myelin formation in vitro.