TEK and ocular hypertension: Tie2 deficiency led to embryonic lethality resulting from the defective vascular remodeling and heart development (Dumont et al., 1994; Sato et al., 1995), and combined deletion of Tie2 ligands Ang1 and Ang2 in mice was also shown to disrupt Schlemm’s canal formation leading to ocular hypertension and glaucoma (Thomson et al., 2014).