We analyzed proportions of Th1 (CXCR3+), Th17 (CCR6+) and TfH (CXCR5+) cells within the CD4+CD45RO+ activated/memory population of a cross sectional group of seropositive Rheumatoid Arthritis patients on stable therapy (Cohort 1), compared to age and gender-matched healthy controls. The gene discussed is CXCR3; the disease is rheumatoid arthritis.