It is important to note that correlations between CXCR5+Th17 cells and disease activity came to light when we analyzed a cohort of subjects with active RA as defined by a decision to change to biologic therapy, rather than based on an arbitrary disease score cutoff in subjects with stable disease/therapy who could represent a very different state of disease. The gene discussed is CXCR5; the disease is rheumatoid arthritis.