The kinetics of granzyme B-producing CD8+ T cells complemented the characteristic of the IFN-γ kinetics with increased numbers and MFI of granzyme B+ cells in CD4-Cre A20fl/fl mice in primary infection at day 7 p.i. but reduced numbers and MFI in reinfected mice at day 53 p.i. (Fig. 2g,h, Supplementary Fig. S2). This evidence concerns the gene CD4 and infection.