EREG, AREG, ERK1/2, MAP3K4, LHCGR and TNIK, among others, were related to the development of CCs in PCOS patients, but the complex genetic etiology of PCOS at different phases of oocyte and CCs development via ARTs is not yet clear13, 14, 15, 16. The gene discussed is AREG; the disease is polycystic ovary syndrome.