Several genes that regulate cell-cell communication were downregulated in PCOS CCs compared with control CCs, such as the integrin (ITG) family (subunits ITGAX, ITGAV, ITGA1, ITGA4, and ITGA6) and gap junction protein alpha 1 (GJA1/CX43) at three stages (Fig. 5B). The gene discussed is ITGA4; the disease is polycystic ovary syndrome.