To determine whether Daxx is involved in Slug-mediated cancer metastasis in vivo, we investigated lung nodule formation in mice intravenously injected with CL1–5 cells stably expressing vector alone, Slug or Slug plus Daxx into NOD–SCID (non-obese diabetic–severe combined immunodeficiency) mice. The gene discussed is SNAI2; the disease is combined immunodeficiency.