PTH and Marchiafava-Bignami disease: Fouque et al. [13] investigated the CKD-MBD marker targets in the KDIGO guidelines by using data from the French Phosphate and Calcium Observatory Study and found low achievement rates for Ca (59.4%), P (32.6%), and PTH (60.7%) targets and an extremely low rate of target achievement for all three markers (12.3%).