CD274 and glioma: As mentioned above, elicitation of antitumor immune responses that reach the tumor is associated with adaptive immune resistance as tumor infiltration by IFN-γ-secreting cells lead to upregulation to PD-L1 in the tumor environment (37), a phenomenon that could be counteracted in a glioma mouse model of tumor-loaded DC vaccination by the concomitant use of anti-PD1 antibodies (162).