IDH1 and glioblastoma: Until now, the most used TSA for GBM immunotherapy are EGFRvIII, a mutant antigen derived from the EGFR protein, which is expressed by 20–50% of GBM patients (110) and IDH1R132H, derived from the IDH1 protein and mainly expressed in grade II and III astrocytoma and patients with secondary GBM (111).