CD274 and neoplasm: Among the many mechanisms evolved by the tumor to escape immune response are the secretion of immunosuppressive cytokines (TGF-β and IL-10, among others), the recruitment or induction of immunosuppressive cells [Tregs, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs)], the depletion of essential nutrients [by indoleamine dioxygenase (IDO) and arginase] and the expression of inhibitory molecules (FasL, PD-L1).