GAD1 and schizophrenia: Reduced message RNA and expression of GAD67 (the synthetic enzyme for GABA) and GAT1 (the transporter that clears synaptic GABA) [58] as well as an apparent compensatory upregulation in postsynaptic GABAA receptors in the dorsolateral prefrontal cortex [57, 61], ACC [58], and prefrontal cortex [45, 59, 62] have also been reported in chronic patients with schizophrenia.