In order to specifically determine the effects of hAAT on NK cell and cytotoxic CD8+ T cell activity in the context of in vivo tumor development, mice were simultaneously inoculated s.c. with CD8+ T cell-sensitive, NK cell-insensitive RMA cells to the right flank (69, 70), and with CD8+ T cell-insensitive, NK cell-sensitive RMA-S cells to the left flank (Figure 3A), and tumor size was determined throughout a 24-day follow-up. Here, CD8A is linked to neoplasm.